Initial screening assays were performed with a large number of typical and atypical antipsychotic drugs. In preliminary studies, we discovered that selected typical and atypical antipsychotic ...

This study revealed an association between elevated hepatic histamine levels and erythropoietic protoporphyria progression.

In the following section, the various methods used to evaluate antihistamines illustrate the developmental process for evaluating the efficacy of the H 1-receptor antagonist desloratadine.

Second-generation H1 antihistamines are the first-line treatment, however, they are inadequate for a substantial number of patients. Standard doses provide relief for only approximately 40% of ...

Antihistamines These medications block histamine receptors in the body. Both H1 and H2 antihistamines may be helpful, with H1 antihistamines (like cetirizine and loratadine) targeting allergic ...

In vitro tests have demonstrated that second-generation antihistamines have improved H 1-receptor specificity and a slower dissociation rate compared with first-generation antihistamines ...

Despite concerns on the major neuropsychiatric side effects for long-term use of H1-receptor antagonist (anti-histamine, AH), one of the major therapeutic tools for allergic diseases, their ...

All compounds are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established. There is no guarantee that they will become commercially available for the ...

An antihistamine is a type of medication that is used to relieve or prevent allergy symptoms such as runny nose, sneezing, and watery eyes. Antihistamines work by blocking histamine — a chemical ...

Many antihistamines can cause drowsiness. It’s not recommended to take them for sleep, as little research backs up their effectiveness. Long-term use may also lead to harmful side effects.

Benadryl‘s active ingredient is diphenhydramine, which works as an inverse agonist at the H1 receptor. This means it reduces allergic reaction symptoms by limiting the effects of histamine ...