Bookkeepers handle more than numbers. They support small and large businesses, manage tax deadlines, and watch for potential pitfalls. FAB 2025 ...

【导读】免疫检查点阻断（ICB）疗法通过靶向程序性细胞死亡配体1（PD-L1）/程序性细胞死亡蛋白1（PD-1）轴以及细胞毒性T淋巴细胞相关蛋白4（CTLA-4），已在多种癌症类型中展现出显著的临床效果。然而，目前只有少数患者能够从ICB疗法中获益，这表明免疫检查点的潜在机制尚未完全明确。2月6日，大连医科大学刘雪峰/詹启敏团 ...

三阴乳腺癌（TNBC）是难治性乳腺癌亚型，传统治疗选择有限，化疗易产生耐药性和副作用，免疫检查点阻断（ICB）疗法仅部分患者有效。然而，许多三阴性乳腺癌肿瘤会产生耐药性，相关的副作用通常需要替代疗法。 免疫疗法，特别是免疫检查点阻断 ...

【导读】将免疫检查点阻断疗法（ICB）与化疗相结合有望治疗三阴性乳腺癌（TNBC），但对其机理仍不完全清楚。在这项研究中，团队整合了已发表的和新的单细胞RNA测序（scRNA-seq）数据，研究了接受紫杉醇（PTX）、纳布-紫杉醇（Nab-PTX）以 ...

为解决免疫治疗中多数患者无响应的难题，韩国延世大学医学院的研究人员开展一碳代谢（1CM）在肿瘤免疫微环境作用的研究，发现 1CM 是增殖性中间耗竭 T 细胞（Texint）的代谢标志。该成果为免疫治疗提供新思路，值得科研人员一读。

A company led by GPs is set to lose its OOH contract for Shropshire, after the local ICB revealed plans to award it to a ...

Niranjan Chandra Debnath has joined Investment Corporation of Bangladesh as managing director through a notification issued ...

A new diagnostics hub is on track to open in May, according to an NHS body. The Leicester, Leicestershire and Rutland Integrated Care Board (LLR ICB) said the £24.6m facility would provide about ...

Dental patients in the East of England will have access to almost 70,000 new, urgent appointments, the government announced.

The Bangladesh Securities and Exchange Commission (BSEC) has formed a three-member committee to review the overall operations of three merchant banks in the stock market. ICB Capital Management, ...