Taken together, our data reveal different IgA class-switching capacities of adaptive FoBs versus innate ... lower panel), suggesting that the spleen is a main site for the formation of IgM-producing ...

We found that dietary antigens contribute to IgA production in PPs through induction of follicular helper T cells and germinal center B cells. The role of dietary antigens in the PP responses was ...

Preclinical studies using transgenic mice expressing human CD19 have shown that pre-B cells and their malignant counterparts, as well as pre-existing antibody-producing and autoantibody-producing ...

This approach allowed us to achieve high coverage for the obtained libraries (Table S1) to reveal information on clonal composition, CDR3 properties, IgM/IgG/IgA isotypes ... infiltrating B cells ...

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...

Lain, B. and Zarbis-Papastoitsis, G. (2011) A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line. Biotechnology Journal ... (2003) ...

Your body can produce an infinite number of binding sites to bind to antigens ... It accounts for 15% of all antibodies in the human body and is produced by B cells and secreted from the lamina ...

Your body can produce an infinite ... the human body and is produced by B cells and secreted from the lamina propria, a thin layer within mucosal tissues. IgA is one of the body's first-line ...