IL - 12 驱动淀粉样脑的病理 ：通过基因敲除实验，研究人员发现删除 IL - 12 特异性受体基因 Il12rb2 可显著降低 APPPS1 小鼠的淀粉样蛋白（Aβ）负担，而删除 IL - 23 受体则没有效果。这表明在淀粉样脑环境中，IL - 12 是驱动 AD 病理的关键因素。

The researchers focused specifically on the IL23R gene, which plays a key role in immune regulation. "The exact causes of chronic inflammatory bowel diseases remain unknown. However, previous ...

Mouse and human studies highlight the IL23–IL23R axis as a target for development of novel therapies for IBD. An IL12 p40 monoclonal antibody that neutralises IL12 and IL23 may be an effective ...

在复制阶段，7 种蛋白质（IL23R、ERAP2、IFNLR1、KIR2DL3、NEO1、CLSTN3 和 POLR2F）在 FinnGen 数据集中成功得到验证（ ） 。其中，遗传预测的 NEO1 水平较低与 PsA 风险增加相关，而其他 6 种蛋白质（IL23R、ERAP2、IFNLR1、KIR2DL3、CLSTN3 和 POLR2F）水平升高与 PsA 风险增加相关。

aMedical Clinic 1, Department of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany ...

Collaborative Innovation Center for Modern Grain Circulation and Safety, Jiangsu Province Engineering Research Center of Edible Fungus Preservation and Intensive Processing, College of Food Science ...

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is widely assumed that such alleles exert small regulatory effects on the expression of cis-linked genes.

Objectives To compare the prevalence, clinical and radiographic characteristics of psoriatic spondyloarthritis (PsSpA) in psoriatic arthritis (PsA), with ankylosing spondylitis (AS). Methods A ...