Scientists at the University of São Paulo analysed blood samples donated by six serodiscordant couples – the situation one ...

2002). By contrast, organ/tissue-specific promoters and inducible promoters can regulate gene expression more precisely in terms of time and space, thus making up for the deficiencies of constitutive ...

Oncolytic viruses are therapeutic agents used for in situ immunization in cancer immunotherapy. Unfortunately, its efficacy is particularly limited in solid tumors expressing stimulator of interferon ...

Researchers at Cellectis leveraged gene editing to create a CAR T cell that acts in an IF/THEN system. Traditional methods to develop CAR T cells that use the patient’s cells introduce challenges ...

CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

During the COVID-19 pandemic, health worker Maria Tereza Malheiros Sapienza's curiosity was aroused by her immunity to ...

However, I also highlight some of the gastrointestinal data that does not fit this simple tidy paradigm, particularly with respect to the inducible form of nitric oxide synthase (iNOS ... that one ...

Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional ...

To explore gene therapy approaches relevant to the inhibition ... establishing NF-κB as a principal mediator of inducible chemoresistance. Our results with TNFα and camptothecins provide a ...

Inducible IL-17A and TNF production can be robustly inhibited in vitro ... Transcript analysis was performed by qPCR using the Biomark HD gene expression system (Fluidigm); values displayed are log ...