Methods: Here, we assess the efficacy of clinically usable CAR-engineered NK cell line NK-92/5.28.z against ErbB2-positive RMS in vitro and in a metastatic xenograft mouse model. Results: Our results ...

There are 33 mammalian tetraspanin proteins, each with characteristic structural features, including a conserved CCG motif in the large extracellular loop. Genetic evidence in fungi, worms, flies ...

从机制上讲，TDEs 携带的货物在引导 CTCs 到达次级器官方面起着重要作用。例如，在乳腺癌的肺转移过程中，TDEs 携带的 α6β1 和 α6β4 整合素上调肺成纤维细胞和上皮细胞中 S100 蛋白的表达，启动转移前微环境的形成。同样，胰腺癌细胞 TDEs 携带的 αvβ5 整合素 ...