Loss of normal p53 function has been associated with resistance ... specific since we found that the cells in organs such as liver, lung, muscle, bone marrow, and intestinal crypts were not ...

Moreover, P53 knockout in mice led to downregulated expression of apoptosis signaling in the liver. Mechanistically, P53 may ...

Researchers found that the loss of p53 function led to the secretion of IL-34 directly. But the blockade of IL-34 restrained the growth of liver cancer with p53 inactivation, and thus prolonged ...