Mouse oocytes undergo drastic changes in organellar composition and their activities during maturation from the germinal vesicle (GV) to meiosis II (MII) stage. After fertilization, the embryo ...

Recent studies have identified dynamic membrane contact sites between mitochondria and lysosomes, independent of mitophagy and the lysosomal degradation of mitochondrial-derived vesicles (MDVs), ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a ...

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Researchers published their results in the Journal of Cell Biology on January 3 ...

The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...

Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

Unlike the many studies into the intrinsic immunomodulatory properties of natural EVs for therapeutic effects, the development of an SP-A-EV drug delivery system achieved more specific goals by ...

The completed vesicle fuses with the vacuole, the yeast analogue of the mammalian lysosome. The larger size of the vacuole allows the release of the inner single-membrane compartment of the Cvt ...

The autophagosome then fuses with another type of vesicle called lysosome. The fused stage is called autolysosome. The autolysosome ultimately matures into lysosome, where the waste is degraded by ...

Endoplasmic reticulum (ER) stress is a general term for representing the pathway by which various stimuli affect ER functions. ER stress induces the evolutionarily conserved signaling pathways, called ...