Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...

Why is MYCL1 so different? Given that so many viruses harness MYC to promote their own life cycle (for examples see Refs 289, 290), it is likely that the cancer cell has devised similar mechanisms ...

Known as c-Myc, the protein is encoded by one of the first cellular oncogenes discovered in humans and has since been found to be dysregulated in more than 50 percent of all human cancers. The peptide ...