Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

Thus, an emerging strategy for the treatment of those conditions is to inhibit cellular proliferation by targeting cell cycle regulation. Here we will review the current understanding of the ...

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Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

probably because of the conflict between mitogenic pressure and the inability to proceed through the cell cycle 21. The different cellular context might account for the different effects of HMGA1 ...

Then the ribose 5-phosphate and NADPH were produced through the pentose phosphate pathway (PPP), or enter into the tricarboxylic acid (TCA) cycle in mitochondrion ... PGK1), and LDHA can be ...

An example of target control would be driving a cell to commit to apoptosis (programmed cell death). From the experimental perspective, gene knockout, pharmacological inhibition of proteins, and ...

Hartmut received his PhD from the University of Vienna for his work on ubiquitination and the cell cycle carried out in the group of Jan-Michael Peters. In his postdoctoral work in the laboratory of ...

First Mouse With Two Male Parents to Reach Adulthood Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a ...