撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

为探究胰腺癌（PDAC）表型异质性的遗传机制，研究人员开展 MYC ecDNA 研究，发现其促进肿瘤异质性和可塑性，意义重大。 胰腺癌（Pancreatic Ductal Adenocarcinoma，PDAC）作为一种恶性程度极高的消化系统肿瘤，其预后极差，5 年生存率仅约 10%。在胰腺癌的发生发展过程中，MYC 基因的异常扩增与肿瘤的侵袭性和不良预后密切相关。MYC ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...

The MYC family of proteins ... studied oncogenes and is an excellent target for cancer therapy, based on its p53-dependent and p53-independent oncogenic activities in various cancers.