撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

为探究胰腺癌（PDAC）表型异质性的遗传机制，研究人员开展 MYC ecDNA 研究，发现其促进肿瘤异质性和可塑性，意义重大。 胰腺癌（Pancreatic Ductal Adenocarcinoma，PDAC）作为一种恶性程度极高的消化系统肿瘤，其预后极差，5 年生存率仅约 10%。在胰腺癌的发生发展过程中，MYC 基因的异常扩增与肿瘤的侵袭性和不良预后密切相关。MYC ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Gene therapy holds great promise as a therapeutic approach for combating cancer, with ...

然而，乳腺癌细胞常常对凋亡信号产生耐药性，从而实现不受控的增殖。USPs（如USP22和USP7）调节关键蛋白（如c-Myc和p53），影响乳腺癌中的凋亡。同样，自噬作为一种细胞自我消化机制，在乳腺癌中具有矛盾的作用，既可以抑制也可以促进肿瘤存活。综述讨论了 ...

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...