Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

downregulated β-secretase 1 (BACE1), nuclear factor-κB (NF-κB), and inflammatory factors, activated nuclear factor 2 (Nrf2), and potentially regulated gut microbiota while alleviating oxidative stress ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

Figure 1 Mechanisms of pathogen avoidance. A variety of comprehensive mechanisms are in place to regulate pathogens avoidance, which include those caused by the alteration of aerotaxis, intestinal ...

Defense mechanisms are rooted in Freud’s theory of personality.According to his model, the mind has three dueling forces: the id (unconscious and primitive urges for food, comfort, and sex), the ...

"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory," said Mark Dell'Acqua, professor of ...

These findings highlight lactylation as a potential novel regulatory mechanism in AD progression. Lactylation ... The substitution prevented APP from interacting with BACE1, the enzyme that takes the ...

Here, using in vitro and ex vivo models, we aim the explore the underlying mechanism. Method: RBCs were isolated from healthy C57BL6 mice ... HG-RBCs suppressed Adam10 (α-secretase)-mediated ...

In this Review, we summarise common mechanisms driving acute and long-term side-effects and discuss monitoring strategies for radiotherapy survivors. We explore ways to mitigate toxic effects through ...