Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Here, using in vitro and ex vivo models, we aim the explore the underlying mechanism. Method: RBCs were isolated from healthy C57BL6 mice ... HG-RBCs suppressed Adam10 (α-secretase)-mediated ...

Alzheimer’s disease (AD) is one of the most common diseases of the central nervous system in the middle-aged and elderly population. It is a neurodegenerative disorder, and its main clinical symptoms ...

In this Review, we summarise common mechanisms driving acute and long-term side-effects and discuss monitoring strategies for radiotherapy survivors. We explore ways to mitigate toxic effects through ...

Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K. Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James ...

"These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory," said Mark Dell'Acqua, professor of ...

Colleges and high schools around Mississippi have started to cancel classes for Tuesday ahead of projected winter storms that could leave up to four inches of snow in parts of the state.

The international team describes their results and the underlying molecular mechanism in Cell Metabolism. Ergothioneine is a natural compound found in certain fungi such as oyster or shiitake ...

These findings highlight lactylation as a potential novel regulatory mechanism in AD progression. Lactylation ... The substitution prevented APP from interacting with BACE1, the enzyme that takes the ...

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K. Institute for Theoretical Physics, Department of Physics, Utrecht University, Utrecht, CC 3584, ...