Objective: To compare the efficacy and tolerability of mefloquine and proguanil in malaria prophylaxis in sickle cell anaemia. Design: Nonblind, prospective, multicentre study. Participants ...

Mefloquine (as HCl) 250mg; scored tabs. Give with food and water. May crush tab and mix in water. Prophylaxis: 3–5mg/kg once weekly starting 1 week before departure, continuing during travel to ...