The reason it has received so much attention from the scientific community is that "this was the first evidence that extracellular calcium ions [Ca 2+] could have direct effects on certain cells via a ...

A possible answer is suggested by the dependence of LTP and LTD on the rapid redistribution of AMPA receptors into and out of the postsynaptic plasma membrane. AMPA receptors recycle in the ...

Researchers have discovered a new mechanism that is used by a male sex hormone essential for muscle and bone function. The ...

To create the SNAP-MOP constructs, the full coding sequence for the human MOP (hMOP) was ligated into a pcDNA3.1(+) vector containing the 5-HT 3 receptor membrane localization signal sequence and the ...

Cellular receptors are in many cases itself highly glycosylated polymers on the membrane surface, forming the glycocalix of the cell. A positive carbohydrate-carbohydrate or carbohydrate-protein ...

The findings highlight the significance of frequency-selective cellular responses in developmental biology, providing valuable insights into the intercellular signal transduction mechanisms.

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

TLR4 localizes at the plasma membrane, but it is endocytosed into endosomes upon activation. Upon binding to their respective ligands, TLR signaling is initiated by dimerization of receptors, leading ...

Researchers have discovered a new mechanism that is used by a male sex hormone essential for muscle and bone function. The findings could lead to the development of new drugs with fewer side effects, ...