Mitochondria are cytoplasmic organelles found in most eukaryotic cells. They are formed from an outer membrane, a highly invaginated inner membrane containing cristae, and a matrix. Mitochondria ...

Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication 1. These findings ...

Most of us remember two things from high school biology: that mitochondria are the powerhouses of cells and that we inherit stable sets of chromosomes from our two parents. Both truisms are only ...

Similar to the companion study, Martin et al. found that ROS from nearby mitochondria causes p62 to aggregate, making the repair function of the ESCRT-III complex less effective. "Further research ...

1,3 In recent years, mitochondrial dysfunction has become a possible mechanism that could explain the development of sarcopenia. Transformations in mitochondria function are seen before the loss ...

Researchers uncovered a mechanism called excitation-mitochondrial DNA transcription coupling (E-TCmito) linking neuronal activity to mitochondrial DNA transcription, crucial for maintaining brain ...

Western blot analysis and immunofluorescence assay were used to determine the levels of P62/SQSTM1 and LC3, and autophagic U937 cells were isolated ... Hu, X. Zhou, Y. Zhou, The role of mitochondria ...

The spheroids are visible with H&E staining, but also stain positive for neurofilaments, p62, amyloid precursor protein APP and β amyloid ... AARS2 encodes a t-RNA synthetase responsible for correctly ...

Inhibition of autophagy under hypoxia enhances antigen presentation. In experimental tumors, reducing mitochondrial metabolism through a respiratory complex-I inhibitor increases tumor oxygenation, as ...

The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer.

Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual ...

Barbara Lazarus’ two sons, David and Daniel, were healthy and active kids, but things changed in their early 20s. David developed severe psychiatric symptoms, which were diagnosed as schizoaffective ...