Researchers from the Mitochondrial Medicine Program at Children's Hospital of Philadelphia (CHOP) have better characterized a ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

Human mitochondrial DNA (mtDNA) encodes only 13 proteins — the rest (roughly 99%) are encoded by nuclear genes and imported into mitochondria 3. These organelles normally work in tandem with the ...

Purpose: Accumulation of mitochondrial DNA deletions and the resultant impaired oxidative phosphorylation may play a pathogenic role in the mediation of age-related sarcopenia. Methods ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Active mitochondrial DNA (mtDNA) elimination ...

This was associated with enhanced production of oxidised mitochondrial (oxmt)DNA. OxmtDNA induced ISG expression in healthy PBMC, which was blocked by targeting oxidative stress and intracellular ...

Mitochondria dysfunction has been found to be involved in the development of diabetes in newly published research. Read more!

To do so, the team damaged three components that are essential for mitochondrial function: their DNA, a pathway used to get ...

The difficulties arise when no known mtDNA defect can be found, or when the clinical abnormalities are complex and not easily matched to those of the more common mitochondrial disorders. We will ...

Despite this observation, mitochondrial respiration supported by both carbohydrate-derived substrates (pyruvate) and lipids (palmitoyl-carnitine) was several-fold higher in HER2-driven tumors which ...

The team disrupted three key components essential for mitochondrial function: mitochondrial DNA, a pathway for removing damaged mitochondria, and another that maintains a healthy mitochondrial pop ...