This important study is the first comprehensive analysis of the modulatory effects of nitric oxide (NO) on the response properties of retinal ganglion cells (RGCs) in the mouse retina using two-photon ...

Inherited eye disorders such as retinitis pigmentosa (RP) leave millions grappling with progressive vision loss. At the heart ...

Aim: To determine the transcriptional proximity of retinal pigment epithelium (RPE) cells grown under different culture conditions and native RPE. Methods: ARPE-19 cells were grown under five ...

Two compounds prolonged the survival of photoreceptors in a retinitis pigmentosa mouse model for rod opsin misfolding ...

The following fluorochrome-conjugated anti-mouse monoclonal antibodies were used for flow cytometry ... Figure 2 Immunohistochemistry shows CD8 T cells in the RPE/c and neuroretina after systemic LCMV ...

ONL-1204 is under clinical development by ONL Therapeutics and currently in Phase II for Retinal Pigment Epithelial (RPE) Detachment. According to GlobalData, Phase II drugs for Retinal Pigment ...

More information: Guizhi Guo et al, Disruption of photoreceptor cilia is a critical event in the pathogenesis of retinal degeneration—Insights from N-methyl-N-nitrosourea-induced mouse model ...

A new study reveals the potential of two compounds in treating retinitis pigmentosa, a blinding genetic disorder. These compounds, identified through virtual screening, have shown promising results in ...