More information: Zixuan Wang et al, Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity, Proceedings of the National Academy of Sciences (2025 ...

At the core of this pathway is cGAS-dependent production of the intra- and extra-cellular messenger cGAMP, which activates STING and leads to IRF3-dependent expression of cytokines and interferons.

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.

Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

这项研究揭示了赖氨酸甲基转移酶SMYD3在调节抗先天免疫中的作用，并为影响其激活的IRF3的调节机制提供了新的见解。 狂犬病（RABV）是丽莎属的 ...

小鼠双氢睾酮试剂盒在实际应用中，通过不同的设计，有很多种不同的操作方法，可供大家选择。分别是用于检测抗体的间接法、用于检测抗原的双抗体夹心法以及用于检测小分子抗原或半抗原的抗原竞争法等等。比较常用的是ELISA双抗体夹心法及ELISA间接法。

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