Recent research has focused on understanding the molecular mechanisms underlying ... and aficamten have shown promise in reducing myosin's ATPase activity, which can help alleviate the symptoms ...

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Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

First found in association with endosomal membranes, the V-type H+ ATPase is now also found in increasing examples of plasma membranes where the proton pump energizes transport across cell membranes ...

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

2019). Microtubules are associated with peripheral actin/myosin-enriched lamellae, and they are the scaffold for the unidirectional transport of macropinosomes. Critically, inhibitors of microtubule ...

The reason this paper is so important to many other researchers, says Rayment, is that the "three-dimensional structure [of myosin] gives a molecular framework that is essential for understanding how ...

Stained embryos were dehydrated in methanol, cleared in BABB and imaged by Zeiss LSM 800. Whole mount in situ hybridization of Dll4 were performed using the HCR probe set according to the manufacturer ...

Validated by morphological studies after identification by mass spectrometry. As the molecular mechanisms underlying zymogen granule (ZG) formation, the sorting/packaging of cargo and regulated ...