Although they produce opposite effects on synaptic excitability, both LTP and LTD can occur at the same synapse in response to different patterns of activation of NMDA (N-methyl-D-aspartate ...

1月16日，团队在Cell杂志上首次以原子分辨率呈现出了内源NMDA受体的组装和结构；2月25日，上线Neuron杂志的论文揭示了镁离子调控NMDA受体的分子机制；3月5日，团队联合中国科学院上海药物研究所李扬/郭飞研究组在Science Advances杂志上证实了GluN2D亚型NMDA受体可成为快速抗抑郁药物的新靶点。

LTP requires the activity of NMDA (N-methyl-D-aspartate) receptors, which are composed of NR1 and NR2 subunits. The NR2B subunit is expressed at nascent synapses and is linked to enhanced ...

More recently, Bear's lab showed a different dichotomy. It has long been understood from their seminal work in the 1990s that the flow of calcium ions through NMDA receptor can trigger a form of ...

NMDA receptors, members of the excitatory ionotropic glutamate receptor family, are essential to these processes. They regulate the strength of synaptic connections, playing a critical role in ...