In addition to excessive daytime sleepiness, up to 60% of narcolepsy cases include cataplexy, which is a sudden loss of muscle control. When patients experience intense emotion, either positive or ...

The FDA approves AVDL's Lumryz for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients aged seven years and older with narcolepsy. Avadel Pharmaceuticals PLC (AVDL ...

Orexin receptor activation has been documented to result in an enormously varied set of downstream interactions, involving many key cascades within the signaling milieu. Studies investigating ...

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This important study shows that the activity of hypothalamic hypocretin/orexin neurons (HONs) correlates with body movement over multiple behaviors. Sophisticated techniques and analyses showcase this ...

Circadian rhythms in mammals are regulated by a master circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN), which coordinates rhythmic processes throughout the organism ...

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It warns: "You need to tell DVLA about some medical conditions as they can affect your driving. You can be fined up to £1,000 ...