Figure 2: Classification of the poly-ADP-ribose-polymerase (PARP) family according to the structural model proposed by Kleine et al.7. To identify the PARP10 residues that are post-translationally ...

为探究 PARP 抑制剂耐药机制，研究人员针对 SETD1A 在相关癌细胞中的作用展开研究，发现其可致 ATM 及 BRCA1 缺陷细胞耐药，或为临床提供新方向。 在癌症治疗的战场上，PARP 抑制剂（PARPi）曾被寄予厚望。它就像一颗精准的 “智能炸弹”，专门瞄准那些在 DNA 双链 ...

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are promising cancer treatments because they block a cell’s ability to repair DNA damage. Four PARPis are currently approved for use in the ...

In recent years, targeted anticancer therapies such as poly adenosine diphosphate-ribose polymerase (PARP) inhibitors have gained the attention of researchers across the globe. PARP enzymes play a ...

Pfizer Ltd has announced that the Scottish Medicines Consortium (SMC) has accepted Talzenna (talazoparib) in combination with enzalutamide for the treatment of adult patients with metastatic ...

We are getting questions from farmers and accountants wondering if Pandemic Assistance Revenue Program (PARP) payments are still going to be made in 2023. Many are tidying up taxes for 2023 ...