MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular ...

including pT3-EF1α-c-Met (human c-MET), pT3-EF1α-ΔN90-β-catenin (with N terminal Myc tag), pT3EF1α-c-Myc, pT3-EF1α-HA-myr-Akt (with N terminal HA tag), pT2CAGGS-NRasV12 and pCMV/sleeping beauty ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The carboxyl terminus of Hsc70-interacting ...

M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation When Maralice ...

This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...

Figure 1: Transgene expression and phenotype. Figure 2: K14.MYC2 mice exhibit impairment in wound healing. Figure 3: K14.MYC2 primary keratinocytes exhibit a defect in migration. Figure 4: K14 ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

CXCL3 was correlated with poor survival in human patients with PDAC. Mechanistically, activation of the IL-33–ST2–MYC pathway attributed to high CXCL3 production. The highest level of CXCL3 was found ...

Noxa and ATF4 sgRNA sequences used to construct the knockouts are shown in Supplementary Table 1. 293T cells were transfected with sgRNA vector, psPAX2 (Addgene) and pCMV-VSV-g (Addgene) for 24 h.