For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

Increasing focus is now being placed on the production of Aβ—a process called proteolysis, during which a precursor protein ...

The University of Michigan has synthesized proteolysis targeting chimeras (PROTACs) comprising a von Hippel-Lindau disease tumor suppressor (VHL)-binding moiety coupled to a signal transducer and ...

Son of sevenless homolog 1 (SOS1) is an essential guanine nucleotide exchange factor (GEF) in KRAS-driven tumors, and it also functions as a downstream node protein of BCR-ABL, suggesting its critical ...

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, People’s Republic of China School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou ...