Pharmaengine Inc. and Sentinel Oncology Ltd. have synthesized Wee1-like protein kinase (Wee1) inhibitors and proteolysis targeting chimera (PROTAC) compounds reported to be useful for the treatment of ...

Shanghai Yidi Biotechnology Co. Ltd. has synthesized proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase coupled to an androgen receptor targeting moiety via a linker reported ...

For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

Increasing focus is now being placed on the production of Aβ—a process called proteolysis, during which a precursor protein called amyloid precursor protein (APP) is trimmed by an enzyme called ...

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, People’s Republic of China School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou ...