A study identifies the P2X7 receptor as a driver of post-traumatic epilepsy (PTE) following brain injuries. Blocking the receptor reduced brain hyperexcitability and damage in models.

In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...

These Tregs stay in SLO, and then migrate into tissues once being stimulated. Tregs, regulatory T cells; tTregs, thymic Tregs; pTregs, peripheral Tregs; TCR, T cell receptors; Th1, T-helper 1; Th2, ...

LDL-C can be catalyzed by metal ions (Fenton reaction) to form reactive oxygen species in the intima. Particularly, cardiovascular phagocytes bind lipoprotein particles to promote the formation of ...

Correspondence to Jun Yu, Department of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong; ...

Using a library prepared from the whole mouse liver, we determine the influence of ATP and orthovanadate on the thermal stability of IMPs, including pharmaceutically relevant ATP-binding cassette ABC ...

Molecular fingerprinting of colonic sensory neurons will facilitate drug development in poorly treated conditions, such as IBS. Differential subtype expression of certain receptors likely explains the ...

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When thrombin was generated by the blood coagulation reaction, the platelets were activated by the thrombin through the thrombin receptor PAR-1 pathway. Such platelets could greatly contribute to the ...

Study of 2.4 million participants reveals potential advantages for cardiometabolic and psychiatric conditions alongside increased risks of gastrointestinal and musculoskeletal issues Study ...