Using the LUHMES neuronal cell model, researchers identified and characterized thousands of enhancers active during neuronal differentiation, linked them to target genes, and validated key ...

We also constructed a ‘super-enhancer’ vector (AV.SupEnh), which ... Figure 4: Intermolecular cis activation increases rAAV-mediated reporter gene expression in muscle in vivo.

Although these non-coding regions do not encode proteins, they contain regulatory elements such as enhancer sequences, which play crucial roles in controlling gene expression. Enhancers can ...

A new study reveals how AI-driven deep learning models can decode the genetic regulatory switches that define brain cell ...

Although these non-coding regions do not encode proteins, they contain regulatory elements such as enhancer sequences, which play crucial roles in controlling gene expression. Enhancers can ...

RBPJ is a candidate causal and functional FLS gene based on epigenetic and functional analyses. Three SNPs (rs7441808, rs35944082, and rs874040) within the RBPJ region were selected to confirm ...

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RNA polymerase binds to a region just before the gene, called the promoter, before moving down the DNA to the gene. Enhancers are regions of DNA that act as molecular switches for turning genes on or ...

to link enhancers to their target genes, and finally validate selected interactions. We expand the number of known enhancers active in differentiating human LUHMES neurons to 47,350, and find overlap ...