The mRNA splicing is a multi-step process catalyzed by various small nuclear ribonucleoprotein (snRNP) particles that dynamically assemble, along with other proteins, in a macromolecular machinery ...

Unlike somatic cells, most histones are replaced by protamines for condensed packaging of DNA during spermatogenesis, and only 1% histones are retained in mature mouse sperm (Siklenka et al., 2015).

Indeed, it is widely accepted that one of the crucial steps in carcinogenesis is the impairment of one or more DNA repair systems. Since their original description 25 years ago, there has been no ...