Points are colored by basepairing in the full genome secondary structure model. Nonsynonymous C→U substitutions at basepaired positions are highlighted which rank highly for mutational fitness and ...

According to earlier reports, synonymous substitutions were considered phenotypically silent; thus, such mutations were frequently ignored in studies of viral mutations because they did not directly ...

synonymous, nonsynonymous, stop, 3UTR) for each method and validated them by Sanger sequencing. Out of the variants uniquely found with the Haloplex method, only a single SNV (from 10 which were ...

Background We aimed to identify rare (minor allele frequency ≤1%), potentially pathogenic non-synonymous variants in a well-characterised cohort with a clinical history of exertional heat illness (EHI ...

Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM.

Background: Episodic ataxias are rare neurological disorders characterized by recurring episodes of imbalance and coordination difficulties. Obtaining definitive molecular diagnoses poses challenges, ...

An Indianapolis mother is dead and her boyfriend is in jail accused of reckless homicide and driving drunk while causing a fatal crash on the city's east side.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The antibiotic resistance crisis, fueled by ...

OutSee’s discovery team, from left, are James Peach, chief operating officer, Chang Lu, chief scientific officer and ...

Based on the perceived low efficacy of current therapies targeted to FGFR2 in gastric cancer (GC), the authors investigate an approach which combines SHP2 inhibition with existing FGFR2 inhibitors.