A cancer therapy that uses genetically engineered immune cells, called CAR T-cells, has kept a person free of a potentially fatal nerve tumour for a record-breaking 18 years. “This is ...

Transient mRNA-based CAR T cell therapy has emerged as a promising approach for the treatment of autoimmune diseases. Traditional CAR T cell therapy uses lentiviral or gammaretroviral vectors to ...

Patients with and without preexisting autoimmune or inflammatory disease show similar safety and cancer outcomes after chimeric antigen receptor (CAR) T-cell therapy for cancer. Researchers ...

There were no bands observed for the vector control lane as expected. To assess the cytotoxicity of CD5CAR NK-92 cells against normal T-cells ... of high efficiency CAR transduction that may ...

A mouse study at Memorial Sloan Kettering Cancer Center has found that adding Nef, a protein from HIV, allows donor CAR T cells to avoid detection by the immune system while still attacking tumors. A ...

CAR T-cell manufacturing involves the viral transduction of a transgene into a T cell, which is not typically associated with impaired T-cell genetic health. However, the genomic integration of ...

Types of Treg cell therapy for AIDs. T-regulatory cell-based therapies include: Increase in the number and functional activity of endogenous Tregs and Polyclonal Tregs, which are non-specific methods, ...

Introduction: Antigen binding to the T cell antigen receptor (TCR) leads to the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 complex, and thereby to T cell ...

Like other CAR-Ts, Calibr's therapy is manufactured from a patient's own T-cells, which are harvested and genetically modified to fight cancer before being reintroduced into the body.

As researchers progress towards clinically relevant processes, scaling up production and clarification of viral vectors is an increasingly pressing need. Download this application note to receive step ...