We measured the proliferation potential and immunoglobulins production of siRNA-transfected or plasmid-transfected B cells stimulated with cytosine-phosphate-guanine (CpG) or anti-IgM. We also ...

Macbecin II was identified as a compound that upregulates MHC-I expression, enhancing immune-mediated cancer cell killing. In ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in ...

The ability of the introduced wt p53 to sensitize the transfected SCCHN cells to ionizing radiation was demonstrated in vitro. We also demonstrated that, in vivo when the ligand-liposome ...

ASO delivery and efficacy was first optimized by targeting cardiac troponin T in cardiac iPS-derived organoids: loss of rhythmic contraction in more than 90% of transfected organoids was achieved.

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...

This study makes the fundamental discovery of the first natural animal rhodopsin that uses a chloride ion instead of an amino acid side chain as a counterion. Using a combination of biochemical and ...

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells, improves insulin promoter activity.

Targeting p53 pathways Given its crucial role in preventing cancer, p53 has become a major target for drug development. Over the years, scientists have devised various strategies to target the p53 ...

X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in T-cell, B-cell, and natural ...