By investigating how lipid-soluble Cer is transported between cells, the researchers demonstrated that high-density lipoprotein (HDL) serves as the primary carrier for Cer transport. Upon reaching ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

In the study, the researchers first confirmed that ER-stressed adipocytes secrete bioactive signaling molecules capable of activating the UPR pathway in hepatocytes across tissues. Using lipidomics ...