The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

It will be fascinating to explore whether specific lipid species are involved in engaging, negatively or positively, ER stress pathways, or are produced during the UPR to regulate nuclear hormone ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

When IECs experience high secretory demand or environmental stress, the ER activates the UPR to ensure proper protein folding ...