Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

Scientists have uncovered how developing neurons migrate from the germinal zone, a process critical for proper brain circuit formation.

The assay was carried out using 5 nM USP30 and reactions were started by simultaneous addition of 180 nM ubiquitin-rhodamine 110 to all 384 wells using the FLIPR Tetra (Molecular Devices) dispense ...

A new editorial was published in Oncoscience’s Volume 12 on January 14, 2025, titled “Pomalidomide improved immune profiles ...

Bacterial and viral infections activate the signal transduction networks that regulate the innate immune system, and trigger the production of inflammatory mediators to combat these pathogens.

Ubiquitin ligases facilitate the recycling ... wherein cell–cell contact and Netrin-1 sensing inputs must function for the correct output to be seen. "With other techniques such as single ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

A new editorial was published in Oncoscience's Volume 12 on January 14, 2025, titled "Pomalidomide improved immune profiles in myeloma." ...

Ubiquitin-specific proteases (USPs) play a crucial role in tumor progression, regulating the stability or functions of specific substrate proteins. USP33 expression is altered in several types of ...

The journey of a thousand miles begins with a single step, but for developing neurons, this first step relies on collaboration from multiple signaling pathways.