Figure 1: Domain structure of ubiquitin-specific proteases. DUB activities fall into three major functional categories (Fig. 3). First, ubiquitin can be transcribed from several genes as a linear ...

CHIP mutation prompts the upregulation of cAMP, increasing PKAc and further competitively inhibiting the ubiquitin-mediated degradation of PDE9A ... Two pivotal questions arise. (1) Can PDE9A ...

Pete is joined by his final choice as part of Radio 1 Dance's Future Stars, Deer Jade. FKA Twigs enters Album Mode, and Richard Russell picks his 3.

1Department of Chemistry, Arvinas Operations, Inc., New Haven, Connecticut.

For example, ER stress-induced HSF1 promotes chemoresistance to ubiquitin-specific protease 7 (USP7) inhibitors via the protein kinase R-like ER kinase (PERK) pathway, suggesting that targeting HSF1 ...

Protein kinase B (AKT); hypoxia-inducible factor 1 (HIF-1); high-mobility group box. 1 (HMGB1); interleukin 1β (IL-1β); lactylation (LA); lactate dehydrogenase (LDH); monocarboxylate transporter (MCT) ...

The January show on MCT’s Community Series is new by theater standards: “Waitress” premiered on Broadway back in 2016 and has built a fan base among theatergoers despite the overwhelming ...