are certainly of interest but do not yet provide an informative tool useful in the screening of inhibitors ... steps (ubiquitin tagging, unfolding, and proteolysis) of the ubiquitin/proteasome ...

The clinical success in hematological malignancies of bortezomib has bolstered interest in the development of a new generation of proteasome inhibitors, varying in their mode of action through ...

There are also ubiquitin-like proteins such as NEDD8, ISG15 or SUMO that act as homologous pathways for ubiquitination. Bortezomib was the first-in-class proteasome inhibitor and is currently ...

In March 1 Journal of Clinical Investigation Thomas Zollner and colleagues from JW Goethe University of Frankfurt, Germany, show that proteasome inhibition reduces superantigen-mediated T cell ...

When proteins are ready to be broken down, they are 'tagged' with a molecular marker called ubiquitin so they can be transported to the proteasome. Before the protein enters the proteasome ...