An international team of researchers led by UNSW Sydney medical researchers now have the details on how this novel drug pushes the HIV capsid to breaking point, stopping the virus in its tracks.

Ultimately, the virus uses our body's machinery to produce copies of itself and spread infection. The HIV-1 capsid is formed by a mesh of around 200 protein hexamers and pentamers, arranged ...

The DNA inside a phage capsid is densely packaged, and therefore a strong gate is required to keep it inside. Lhuillier and colleagues, writing in a recent issue of the Proceedings of the National ...

Astellas Pharma and Sangamo Therapeutics have signed a licence agreement for a neurotropic adeno-associated virus (AAV) capsid, STAC-BBB, aimed at treating neurological diseases. Astellas will ...

6 To generate a library of new capsids, Deverman edited a section of the AAV genome that contained a stretch of seven amino acids that he found can tolerate a bit of change but still form a capsid. By ...

Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

FDA guidance states that defective interfering particles, noninfectious particles, empty capsid particles, and replicating recombinant virus contaminants are all concerning impurities in viral ...

The capsid license follows an agreement between Dyno and Roche originally announced in May 2020 and marks Dyno’s first adeno-associated virus (AAV) capsid licensing and partnership completion.