The cytidine analogue, 5-azacytidine (AZA; 5-AZA-cR), is the primary treatment for myelodysplastic syndrome and chronic myelomonocytic leukaemia. However, only ~50% of treated patients will ...

Furthermore, the expression of sfRON was specifically downregulated by 5-azacytidine (AZA). Conversely, AZA could induce the expression of sfRON in sfRON-negative leukemic cells suggesting that ...

By combining venetoclax and 5-azacytidine we've seen enhanced efficacy across a wide range of patient samples. It shows the ...

More information: Lyndsey Flanagan et al, Steroid-free combination of 5-azacytidine and venetoclax for the treatment of ...

The FDA’s approval covers use of Venclexta (venetoclax) in combination with azacytidine, or decitabine, or low-dose cytarabine (LDAC) for newly diagnosed AML in adults 75 years or older ...