Tyrosine phosphorylation on key intracellular residues of EGFR recruits docking proteins, including the SH2 domain-containing proteins Shc and Grb, which in turn couple to Ras. The guanine ...

Patients whose metastatic colorectal cancer has progressed following chemotherapy and who lack mutations in the RAS and BRAF genes (RAS/BRAF wild-type) are typically treated with EGFR inhibitors.

which involved renin-angiotensin system (RAS) inhibition, blood pressure control, and lifestyle management. "These results highlight the importance of considering the 2-year eGFR total slope ...

Assessment of transfer entropy is useful for network analysis of cell signaling network providing information on the network topology and action points of genetic mutations and drug effect, thus will ...

It is a survival and proliferation factor for a variety of tumor types. EGFR signals through the RAS/RAF/MEK/ERK pathway. Upon activation by extracellular ligands, EGFR dimerizes and ...

Further tests confirmed the result. The signalling cascade downstream of EGFR includes proteins such as RAS, RAF, MEK and ERK. Activation of EGFR by epidermal growth factor (EGF) leads to ...