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ESM1 调控关键轴影响卵巢癌顺铂耐药,有望开辟治疗新方向
研究结论和讨论部分指出,顺铂耐药是卵巢癌治疗的关键难题,该研究揭示了 ESM1 与卵巢癌顺铂耐药密切相关,其关键下游基因是 lncRNA GAS5。GAS5 通过竞争性内源 RNA(ceRNA)机制抑制 miR-23a-3p 表达,进而抑制卵巢癌细胞顺铂耐药的发生发展。miR-23a-3p 作为癌基因,通过结合 PTEN 的 3’-UTR 抑制其表达,激活 Akt ...
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