Proteins are biopolymers of amino acids (polypeptides), joined by peptide bonds, that are generated by ribosomes. The amino acid sequence, encoded by its gene, determines a protein’s structure ...

Mass spectrometry-based proteomics is the only method currently available to comprehensively analyse changes in mutant proteomes. Several quantitative methods have been introduced to profile ...

Introduction: Formation of hydroxyapatite in bone, dentin, and enamel occurs at restricted molecular sites of specific extracellular matrix proteins and is controlled by multiple mineralization ...

Acute myeloid leukemia (AML) is a complex and heterogeneous group of aggressive hematopoietic stem cell disease. The presence of diverse and functionally distinct populations of leukemia cells within ...

This valuable study investigated the role of PLECTIN, a cytoskeletal crosslinker protein, in hepatocellular carcinoma development and progression. Using a liver-specific Plectin knockout mouse model, ...

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Computational Biology Facility, University of Liverpool, Crown Street, Liverpool L69 7ZB, U.K. Centre for Proteome Research, Institute of Systems, Molecular and Integrative Biology, University of ...