Sphingolipids and PUFA are crucial bioactive molecules and involved in several fundamental and patho-physiological conditions like asthma, cystic fibrosis, respiratory tract infection and acute lung ...

Lipid second messengers, including phosphatidylinositols, sphingolipids and steroid hormones, bind to proteins to effect changes in their activity and localisation. Local production of lipids can ...

THR-beta agonists are the only medication approved to treat metabolic dysfunction–associated steatohepatitis (MASH), a severe ...

It has become increasingly clear that bone cells, osteoblasts, osteoclasts, and osteocytes, communicate and regulate the fate of each other through RANK/RANKL/OPG, liver X receptors (LXRs), ...

Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...

Department for Innovation in Biological, Agrofood and Forest Systems (DIBAF), University of Tuscia, Viterbo, Italy Introduction: Soil microbiome transplantation is a promising technique for enhancing ...

The spleen is a lymphoid organ that filters the blood. It removes old red blood cells and recycles iron. The spleen contains unique populations of immune cells and is thought to be important for ...

Notch1 is expressed uniformly throughout the mouse endocardium during the initial stages of heart valve formation, yet it remains unclear how Notch signaling is activated specifically in the AVC ...