In this review, we aim to provide molecular and structural underpinnings on endosomal DNA sensor Toll-like receptor 9 (TLR9) and multiple cytosolic DNA sensors including cyclic GMP-AMP ... and they ...

Request permissions for this article. Department of Neurology, Sun Yat-Sen Memorial HospitalSun Yat-sen University Guangzhou 510120 China Brain Research Center, Sun Yat-sen Memorial HospitalSun ...

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Commissions do not affect our editors' opinions or evaluations. A custom domain name is your address on the internet. It makes up part of the URL shown at the top of your browser window and lets ...

Phosphorylation of NKCC1 N-terminal domain (NTD) residues Thr212, Thr217, and Thr230 fosters associations between NTD and C-terminal domain (CTD) and between cytosolic domains and the transmembrane ...

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Cells are preoccupied by the control of cytosolic calcium concentration, and with good reason. Calcium ions shuttle into and out of the cytosol — transported across membranes by channels ...

Figure 2. Regulation of the cGAS-STING pathway of cytosolic DNA sensing. cGAS, cGAMP and STING are dynamically regulated by various modifications in response to DNA attacks, such as phosphorylation, ...