The Discovery of Sotorasib (AMG 510): First-in-Class Investigational Covalent Inhibitor of KRAS G12C
KRAS is one of the most frequently mutated oncogenes in human cancer. Despite more than three decades of research, indirect approaches targeting KRAS-mutant cancers have largely failed to show ...
It’s powered by a 375-horsepower, turbocharged inline-six-cylinder engine (450) or 510-hp, twin-turbo V-8 (580). The ultraluxury Maybach GLS600 and high-performance AMG GLS63 get a twin-turbo V ...
The all-new S-Class is longer and is immediately available with a 510-horsepower V-12 engine as well as a high-performance S65 AMG model. The two-door version of the S-Class, the Mercedes-Benz ...
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