进一步的实验揭示了TP63这个癌基因是ALDH3A1的“总开关”。它直接激活ALDH3A1基因，触发保护机制。当研究团队关闭TP63时，癌细胞失去了抵抗铁死亡的能力，但当重新激活ALDH3A1时，它们又恢复了保护作用。

A research team led by Prof. JIANG Yanyi from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, ...

Further experiments revealed that TP63, an oncogene, acts as a "master switch" for ALDH3A1. It directly activates the ALDH3A1 gene, triggering the protective mechanism. When the researchers turned ...

In this study, the researchers found that the protein ALDH3A1, known for its role in detoxifying harmful substances in the body, is overactive in SCC cells. This protein acts as an "antioxidant ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...