This study demonstrates the critical role of Afadin on the generation and maintenance of complex cellular layers in the mouse retina. The data are solid, which provides important insights into how ...

A groundbreaking study in Nature Cardiovascular Research uncovers promising drug targets for heart failure (HF) and its subtypes, offering new hope for precision medicine in cardiology. A recent study ...

Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

In general, chemotherapy medications work by attacking cells or by preventing them from growing and dividing. Cancer cells tend to grow and divide rapidly and uncontrollably, and many chemotherapy ...

Recognition of specific antigen through the B-cell receptor (BCR) stimulates the activation of B cells, which ultimately results in the production of high-affinity antibodies and the provision of ...

The pre-B-cell receptor (pre-BCR), which comprises two Igμ chains and two germline-encoded surrogate light chains (SLC) that are associated with the signalling subunits Igα and Igβ, is formed ...

10, GraphPad Software, La Jolla, California, USA). An unsupervised hierarchical clustering algorithm (Ward’s linkage algorithm, euclidean distance as metric scale) was performed to estimate the B-cell ...

B cells are involved in autoimmune diseases through both antibody-dependent and -independent mechanisms. Broad depletion of B cells using monoclonal antibodies (mAbs) such as anti-CD20 or CD19 were ...

3 German Centre for Infection Research (Deutsches Zentrum für Infektionsforschung DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany 4 Computational Biology for Individualised Medicine, ...

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

Neurons are cells in the body that are responsible for transmitting electrical signals through the nervous system. Different types of neurons affect the ability to move, which begins as an impulse, or ...

It feels like the Splinter Cell remake has been on its way for a while now, which isn't helped by the fact it's been over three years since we heard anything official about the game. From what we ...