UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, Pennsylvania 15232, United States Department of Computational and Systems Biology, University of Pittsburgh, 3420 ...

To investigate the mechanisms of solid tumor heterogeneity, we developed a modification of the NOD/SCID mouse model in which human breast cancers were efficiently propagated in the mouse mammary fat ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

这就像是拔掉了乳腺癌干细胞的 “能量源”，使得 ALDH?细胞群体和 CD44?/CD24?细胞群体减少，乳腺球的大小、数量和形成效率都明显下降。同时，YAP/TAZ 的缺失还会影响氧化还原平衡，导致 NRF2 表达降低，KEAP1 表达增加，细胞内活性氧（ROS）水平升高，抗氧化剂超 ...

为解决急性肾损伤（AKI）机制不明及治疗策略缺乏的问题，南方医科大学研究人员探究 CD44 在 AKI 中的作用。结果发现 CD44 可加重 AKI，抑制它或成治疗新策略。推荐科研读者阅读，以了解 AKI 新机制与潜在疗法。 在当今社会，急性肾损伤（AKI）就像一个隐藏在 ...

细胞增殖的周期性是生物的一个基础特征。同样适应性免疫的抗原特异性T和B细胞通过克隆扩增产生大量短寿命的效应细胞和一些长寿命的记忆细胞。T细胞主要有两个亚群：辅助性CD4T细胞和细胞毒性CD8T细胞；随着时间推移，记忆性CD4+T和CD8+T通过细胞死亡、存活 ...

T cells play a crucial role in the adaptive immune system’s defense against external invasion. To distinguish between self and non-self, T cells use their T cell receptors (TCRs) to recognize ...

Mortality from triple negative breast cancer (TNBC) is significantly higher in African American (AA) women compared to White American (WA) women emphasizing ethnicity as a major risk factor; however, ...

Evaluation of Culture Purity, Cell Cycle Distribution, and Expression of CD24/CD44 by Flow Cytometry To evaluate cell purity, cells were fixed for 15 min in 4% formaldehyde, permeabilized in precooled ...

washed with blocking buffer [1% FCS/phosphate-buffered saline (PBS)], and incubated with 0.4 ml of antibody to CD24 (APC-H7 CD24, BD Pharmingen) or CD44 (APC CD44, BD Pharmingen) in blocking buffer (1 ...