Here we developed a cost-effective high-throughput multiplexed single-cell RNA-seq combined with epitope tagging (CITE-seq) to determine how classic activators of T cells (anti-CD3 coupled with ...

We identify direct mRNA targets of the translational repressor Pumilio, finding that mRNAs bound by Pumilio encode proteins enriched in synaptosomes. Pumilio differentially binds to RNA isoforms of ...

Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain refractory to treatment. Autologous haematopoietic stem cell transplantation ...

Investing in small-to-mid-market private investment funds and privately held companies, predominantly in the US, to achieve capital growth over a five to ten-year investment horizon. The investment ...

Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK ...

Erk1/2 and CD3-ε, respectively. Upon CCL19 stimulation, quantifications of the amount of Fam65b present in the cytosol exhibited an increase, with a concomitant decrease in the membranous fraction ...

Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein ...